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Katy Muzikar
Graduate Student

Artistic rendering of an atomic force microscope (AFM) probing a DNA array attached to a reflective mica landscape. Small molecules known as polyamides (chemical structure is shown) have sequence-selectively bound to identify pre-designed portions of the DNA (indicated by the green helices). Large protein molecules attached to the polyamide can be visualized by the AFM needle, which reads the topographical surface of the DNA landscape. An actual AFM image of this event is shown to the upper right, the white stripes indicate the raised protein "bumps" on the DNA array. The accompanying height readout is shown below the image, indicating a distinct pattern of bumps corresponding to the polyamide binding pattern. (Modified from Angew. Chem. Int. Ed. 46 (2007), 7956-7959.)


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